5-Amino-1MQ is a synthetic small molecule and a selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), which plays a key role in regulating metabolism, fat storage, and cellular energy balance. By blocking NNMT, 5-Amino-1MQ helps preserve nicotinamide for conversion into NAD+, a critical coenzyme for mitochondrial function, energy production, and DNA repair.
Key Mechanisms and Benefits
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Boosts NAD+ Levels: Inhibiting NNMT increases availability of nicotinamide, enhancing NAD+ synthesis and supporting sirtuin activity linked to longevity and cellular health.
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Promotes Fat Loss: Preclinical studies show it reduces adipocyte size and fat mass by improving fat oxidation and insulin sensitivity, particularly in high-fat diet models.
- Improves Metabolic Health: Associated with better glucose tolerance, reduced inflammation, and enhanced insulin responsiveness, making it of interest for metabolic syndrome and type 2 diabetes research.
- Supports Muscle Regeneration: Research indicates NNMT inhibition may improve muscle stem cell function and tissue repair, relevant to sarcopenia and recovery from injury.
Dosage and Use
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Typical Dose: 50–100 mg per day, often split into two doses (e.g., 25–50 mg twice daily).
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Cycle Length: Commonly used in 4–6 week cycles, followed by 2–4 weeks off to prevent adaptation.
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Administration: Available in oral capsule form, offering better bioavailability than injectable peptides.
Safety and Considerations
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Not FDA-Approved: Classified as a research chemical, not intended for human medical use.
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